Doxycycline intake and distribution in the body of broiler chickens with ornithobacteriosis

Abstract

The clinical efficiency of the anƟbioƟc is determined by its distribuƟon in organs and Ɵssues, the ability to penetrate the physiological and pathological barriers of the body. The arƟcle presents the results from a study of the intake, distribuƟon, and excreƟon of doxycycline hyclate – the acƟve substance of the anƟbioƟc pollodoxin from the body of broiler chickens (the Cobb-500 cross) with ornithobacteriosis. It has been established that 24 hours aŌer the pollodoxin soluƟon applicaƟon in broiler chickens with ornithobacteriosis, the highest content of its acƟve substance (doxycycline hyclate) was found in the lungs, liver, slightly less – in the kidneys, and least – in the heart and pectoral muscles. AŌer 48 and 72 hours, the content of doxycycline hyclate increases in the liver, kidneys, heart, and pectoral muscles compared to 24 hours, while in the lungs decreases slightly aŌer 48 hours and does not differ from it aŌer 72 hours. At 96 hours, the content of doxycycline hyclate in the kidneys, lungs, and pectoral muscles reaches maximum values; in the liver it is smaller than the previous one (72 hours), while in the heart it does not differ from it. Doxycycline hyclate does not show cumulaƟve properƟes and “organ affiliaƟon” during 96 hours of entry into the body of broiler chickens with ornithobacteriosis. AŌer 24 hours of disconƟnuaƟon of pollodoxin use (120 hours of the experiment), the content of doxycycline hyclate in all studied organs decreases but remains high enough, indicaƟng a relaƟvely long eliminaƟon half-life and anƟmicrobial acƟon. PharmacokineƟc indicators will allow the doctor to determine an effecƟve drug that will provide a therapeuƟc effect and will prevent the development of resistance of microorganisms.