Synthesis of functionalized selenium nanoparticles with the participation of flavonoids

Abstract

Nanoparticles synthesized using plant extracts or phytocomponents are of great importance in the development of various therapeutic and diagnostic tools. Biogenic, "green" synthesis of metal nanoparticles, metal oxides and metalloids with the participation of plants and microorganisms, combines biological principles with biochemical approaches to obtain nanosized functional particles with the necessary properties and non-toxicity, easy reproducibility and cost-effectiveness. Various strategies and biomodifiers, in particular with the participation of flavonoids, are used for surface modifications / functionalization of these nanomaterials. Quercetin from the group of flavonoids has a protective effect on cancer and cardiovascular disease, chronic inflammation, oxidative stress and neurodegenerative pathologies due to its anti-radical and anti-inflammatory properties, however, its poor bioavailability inhibits potential beneficial effects. Our research focuses on the synthesis of selenium nanobioconjugates with quercetin to improve its solubility and to develop tissue-specific delivery systems.