Osseointegration properties of domestic bioactive calcium phosphate ceramics doped with silicon

Abstract

Introduction: The relevance of this study lies in the fact, that today the search for biocompatible materials for the management of bone defects is of importance. Such materials could become an alternative to transplants. For the replacement of bone defects, two-phasic bioactive ceramics of hydroxyapatite and β-tricalcium phosphate is a very attractive biomaterial due to its excellent biocompatibility and osteoconductivity, but the results of its use are quite controversial due to insufficient bioactivity. The purpose of this work is to investigate the osseointegration properties of two-phase bioactive ceramics doped with silicon (HTdSi), both as a single component and a component in combination with platelet-rich fibrin, as well as in comparison with the well-known imported analogue – BIO, which consists of βtricalcium phosphate, also as an independent component and a component in combination with platelet-rich fibrin. In the experiment, the rabbits of the New Zealand white breed at the age of 3 months and with an average weight of 2.5 kg were used. The terms of implantation are 30, 60, 90 and 180 days. The advantages of the domestic bio-composite are substantiated on the basis of clinical, radiological and histological studies. Material and methods: In the experiment, the rabbits of the New Zealand white breed at the age of 3 months and with an average weight of 2.5 kg were used. The terms of implantation are 30, 60, 90 and 180 days. Results: The osteointegration properties of two-phase bioactive ceramics doped with silicon (HTdSi), both as a single component and in combination with platelet fibrin, were investigated, as well as in comparison with the known imported analog - BIO, which contains β-tricalcium phosphate, both as a single component and in combination with platelet fibrin. Conclusions: The advantages of domestic biocomposite are substantiated on the basis of clinical, radiological and histological studies.